Princess Friederike Caroline Luise of Hesse-Darmstadt (20 August 1752 – 22 May 1782) was a member of the House of Hesse and by marriage a Duchess of Mecklenburg-Strelitz.

Friederike was born in Darmstadt, the eldest daughter of Prince George William of Hesse-Darmstadt, second son of Louis VIII, Landgrave of Hesse-Darmstadt, and his wife, Countess Maria Louise Albertine of Leiningen-Falkenburg-Dagsburg.

Friederike married Duke Charles of Mecklenburg-Strelitz on 18 September 1768 in Darmstadt.

Friederike is buried in the royal crypt of the church of St. John the Baptist in Mirow.

Friederike is the most recent common matrilineal ancestor of Harald V of Norway (via Louise), Henri, Grand Duke of Luxembourg (also via Louise), Willem-Alexander of the Netherlands (via Charlotte Georgine), and Frederik X of Denmark (via Frederica).married second in 1798 to Prince Frederick William of Solms-Braunfels and had issue; married third in 1815 to Ernest Augustus, King of Hanover, and had issue;