Princess Marie of Hesse-Kassel (German: Marie Wilhelmine Friederike von Hessen-Kassel; 21 January 1796 – 30 December 1880) was the consort of George, Grand Duke of Mecklenburg-Strelitz.

Through her father, she was a great-granddaughter of George II of Great Britain.

In 1803, her uncle's title was raised to Elector of Hesse — whereby the entire Kassel branch of the Hesse dynasty gained an upward notch in hierarchy.

Her sister Augusta married Prince Adolphus, Duke of Cambridge, the seventh son of George III of the United Kingdom.

On 12 August 1817 in Kassel, Marie married George, Grand Duke of Mecklenburg-Strelitz, son of Charles II, Grand Duke of Mecklenburg.