Princess Luise Dorothea Sophie of Prussia (29 September 1680[1] – 23 December 1705[2]) was Hereditary Princess of Hesse-Kassel by marriage to Frederick, Hereditary Prince of Hesse-Kassel.

She was the daughter of Frederick I, the first king in Prussia, by his first wife Elisabeth Henriette of Hesse-Kassel.

Luise Dorothea was married in Berlin 31 May 1700 in a grand ceremony which took place during several weeks to great costs.

Conrad Mel wrote Font Legatio orientalis at the occasion.

During her five years of marriage, Luise Dorothea suffered from poor health.