The Princess Margaret Hospital was a large hospital situated in Okus Road, Swindon, Wiltshire, England.

It was managed by the Swindon and Marlborough NHS Trust.

The hospital, which was built to replace the aging Victoria Hospital, was opened in phases: the outpatients department was opened in 1959 and the main block was opened by Princess Margaret in April 1966.

It was the first purpose-built general hospital to be funded by the NHS.

[2] The building was demolished in 2004 and the 25-acre site was redeveloped as housing.