Through her marriage to Archduke Karl Salvator of Austria, Maria Immaculata became an Austrian archduchess.

Her mother, Maria Theresa, detested parties and court life and instead, she devoted herself to the care of her children and sewing.

After the fall of the Kingdom of the Two Sicilies during the Expedition of the Thousand, the royal family fled to Rome where they resided at the Quirinal Palace at the invitation of the Pope Pius IX.

[1] In late September 1878, after Maria gave birth to a daughter in Baden, Emperor Ferdinand himself visited to attend the christening of Maria Immaculata Raineria; the archduchess was congratulated with a torchlight procession and presented a large bouquet of flowers by mayor of Baden Count Christalnigg.

Eventually, Empress Elisabeth's youngest daughter Archduchess Marie Valerie married Maria Immaculata's son Franz Salvator.