Pristimantis simonsii is a species of frog in the family Strabomantidae.

It is endemic to Peru and known from humid puna grassland in the northern part of the Cordillera Occidental in the Cajamarca Region, at elevations of 3,050–3,760 m (10,010–12,340 ft) asl.

Snout rounded, as long as the diameter of the orbit j canthus rostralis distinct; nostril a little nearer the tip of the snout than the eye; interorbital space as broad as the upper eyelid; no tympanum; no eustachian tubes.

Fingers and toes moderate, slightly swollen at the end; first finger not extending as far as second; toes free; subarticular tubercles moderate; two rather large, feebly prominent metatarsal tubercles.

The upper parts with porous smooth warts, some of which are confluent into longitudinal folds on the body; the throat, belly, and lower surface of thighs coarsely granulate.