Professor Blastoff was a weekly comedy audio podcast, which was released every Tuesday and lasted four years from May 15, 2011 to July 21, 2015.

[6] In the Spring through Fall of 2012, Notaro was absent from a lot of the podcast episodes due to various sicknesses she experienced in a short time period, which she documented on her Grammy-nominated album, Live.

[7] The podcast could be streamed from the Earwolf website or downloaded from iTunes up until June 14, 2016, when it was switched to exclusively being hosted by Stitcher Radio.

[8] Many notable people in the world of comedy, music, television and film have appeared on the podcast, including Amy Schumer, Ira Glass, Aisha Tyler, Pete Holmes, and Marc Maron.

Blastoff, Ph.D., got lost in space and reports back findings to his abandoned basement, or the "Hatch," via radio signal and determines the subject of each episode.