[1] Created for use on Microsoft Windows and macOS laptops or desktops, Progression focused on composition for guitar, but could also be used to compose for keyboards (piano, electric piano, and clavinet), bass (electric and upright), and drums (standard drum set).

[2] As of April 2019, Progression is no longer available for sale in the PreSonus online store, nor via dealers worldwide.

[3] Users could compose in Progression both in standard notation and tablature ("tab") at the same time and hear their musical ideas played back with digital samples from Victor Wooten (bass), Roy "Futureman" Wooten (drums), Neil Zaza (guitar), and others.

[4] Playback features included built-in effects and amp simulators, customizable bends and slides, and continuous real-time control of playback tempos.

Other input options included an interactive fretboard (that a user can add/remove strings and assign alternate tunings) and chord library.