Promazine (brand name Sparine among others),[2] is used as a short-term add-on treatment for psychomotor agitation.

[4] Common side effects include agitation, amenorrhea, arrhythmias, constipation, drowsiness and dizziness, dry mouth, impotence, tiredness, galactorrhoea, gynecomastia, hyperglycemia, insomnia, hypotension, prolonged QT, seizures, tremor, vomiting and weight gain, among others.

[7][8] It does not provide analgesia and is not a very strong sedative, hence it is used combined with opioids or α2 adrenoreceptor agonists, such as clonidine, or both.

[9] Low blood pressure, fast heart rate and paralysis of the penis are side effects.

[8] Additionally it is used to lower blood pressure in animals with laminitis and kidney failure.