Promephitis is an extinct genus of mephitid, of which several species have been described from the Miocene and early Pliocene of Europe and Asia.

The fossil remains of the Promephitis species, like all members of the skunk family (Mephitidae), have a significant extension of epitympanic recess, a chamber of the middle ear, into the region of mastoid and squamous parts of the temporal bones.

The genus Promephitis also shows a distinctive structure of the premolar tooth P4 as well as a very small P2, through which they are distinguishable from other genera.

[2] The genus and the type species Promephitis larteti were described in 1861 by Jean Albert Gaudry from a fossil found at Pikermi in Greece.

[1] Within the recent genera, the stink badgers represent the earliest genus; the clade comprising them with Promephitis and Palaeomephitis is considered to be a sister group to all other skunks living today and other fossil forms.