John Prophet, a poor and homeless man living in the World War II era, volunteers to participate in the medical experiments of Dr. Horatio Wells, a time-traveling scientist from the future.

Prophet is engineered to serve the evil Phillip Omen and programmed with murderous instincts.

[1] Stephen Platt, Prophet artist from 1994 to 1996, explained that the character "feel[s] responsible for the things that people forced him to do, even though he can't remember them.

[1] Rob Liefeld told Wizard magazine in 1994 that he was inspired by Gene Roddenberry and Steven Spielberg to create Prophet.

Written by Brandon Graham with art by Simon Roy, Prophet continued the numbering of the previous series and launched with issue #21 in January 2012.

The entire storyline has been reprinted in 5 volumes, including the 2 issue Prophet: Strikefile miniseries.

In a review of Prophet #21, Newsarama's Scott Cederlund wrote that "Graham and Roy's revamping of an old Rob Liefeld character has a wild, untamed vibrancy that makes it more of a comic of today and not a rehash of a 15-year-old concept that only lasted for under 20+ issues.

"[7] Charles Hatfield of The Comics Journal, in a review of issues #21 and #22, remarked that despite the book's "many obvious points of reference, Prophet casts its own spell, evoking its own fantastical reality.

Club said that issue #26 "shows the stunning storytelling possibilities that arise when an established character is paired with an innovative creator."

Sava added that "the main lesson that Marvel and DC can take away from the success of Prophet is that the best way to revitalize a property is by finding people who create good comics and allowing them to do whatever the hell they want with it.

[14] On October 7, 2021, it was announced that Jake Gyllenhaal would star in the titular role with Sam Hargrave directing.

Additional artists included Liefeld, Jim Lee, Todd McFarlane, and Mike Deodato.