It is located in downtown Columbia, South Carolina, and was founded by the Sisters of Charity of Saint Augustine in 1938.

The facility specialises in cardiac care, provided through the Providence Heart & Vascular Institute, which is recognized statewide as a referral center for the prevention, diagnosis and treatment of cardiovascular disease.

[1] Providence Hospital Northeast was established in 1999 and offers a range of medical services in surgery, emergency care, women's and children's services and rehabilitation.

The board of Medical University of South Carolina voted to acquire the hospital system in 2021.

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