When she was ten years old, her family moved to Santa Ana City, where she attended María Luisa de Cristofine's elementary school.

In 1930, she intended to run as a candidate for the presidency of the Republic, even though the Salvadoran legislation did not recognize women's right to vote.

Her government platform included the support of unions, honesty, and transparency of the public administration, the limitation of the distribution and consumption of liquor, the respect of the freedom of worship and the recognition of "illegitimate kids".

One of the advocates of her candidacy was the philosopher, teacher, writer, and congressman Alberto Masferrer, who, in the Newspaper Patria, stated:Prudencia Ayala defends a just and noble cause, which is the women's right to vote and to hold high positions.

Her government program is not inferior in justification, practical sense and simplicity, than other candidates that are taken seriously.Finally, her application was rejected by the Supreme Court, but the debate that followed the intent of her nomination sparked the feminist movement that permitted the women suffrage right to be reconsidered in 1939,[4] and that in the Constitution of 1950, under the approval of the President Oscar Osorio, it gave legal recognition of women's rights in El Salvador.

[5][full citation needed] Prudencia Ayala died on 11 July 1936, away from the political arena, but close to the masses and social movements.