It is endemic to Oaxaca, Mexico, where it is known from the northern slopes of Sierra de Juarez at elevations of 800–1,390 m (2,620–4,560 ft) above sea level.

The specific name orchileucos, from the Greek orchis (=testicle) and leukos (=white), refers to the white color of the outer epithelial layer of the testes and vasa deferentia in adult males (the latter might have scattered melanocytes).

This trait distinguishes it from Pseudoeurycea orchimelas with black testes and vasa deferentia.

They live in leaf litter terrestrially and fossorially;[1] most specimens have been recovered by turning rocks and stones or in and under rotting logs.

[2] The species is threatened by habitat loss (deforestation) caused by expanding subsistence farming and human settlements and by logging.