Found in North America, it is a plant pathogen that infects grape, causing a disease known as "angular leaf scorch".

[3] As the lesions become larger late in the growing season, necrosis can cause premature defoliation, thus inhibiting photosynthesis of the plant host.

Ascospores are forcibly released from the asci at the end of a rain event following a dry period and are splashed by water or carried by wind to host leaves and flower stems.

[3] Removal of other susceptible hosts of the family Vitaceae, like Parthenocissus quiniquefolia can reduce the likelihood of foreign P. tetraspora inoculum to enter where one doesn't want disease.

[3] Foliar fungicide sprays are recommended to control P. tetraspora because the ascospore lands on, infects, and penetrates the leaf.