Pseudopterosin A

Pseudopterosin A is a diterpene glycoside isolated from the gorgonian sea whip Antillogorgia elisabethae, found in the Bahamas and Florida Keys.

[1] Pseudopterosins A-D, which differ in the degree of acetylation at the sugar ring, were first isolated and reported in 1986.

[1] Samples of P. elisabethae from the Bahamas are found to have higher concentrations of pseudopterosins than populations from the Florida Keys, which have a greater diversity in diterpene structures.

[4] Commercially, pseudopterosins are found in skin creams as topical anti-inflammatory agents.

The proposed synthesis of artificial anti-inflammatory metabolites is modeled after pseudopterosins and is based on the bicyclic seco-pseudopterosin structure 6.

GPP cyclization to elisabethatriene
Overall biosynthetic scheme for pseudopterosin A
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General structure of seco -pseudopterosins