It was founded on June 8, 1892, "to maintain the standards of the profession, to encourage scientific investigation and literary culture."

[3] Psi Omega's international reach extended to three Canadian chapters, located in Toronto, Montreal, and Halifax.

[4] Government is maintained by a triennial convention called the grand chapter, with recess administration held by a board of officers as the National Council.

Where formerly the national chief officer was called the grand master, in more recent times this role is held by a president.

Alumni chapters consist of initiated fraternity members who have attained either the DDS (Degree of Doctor of Dental Surgery) or DMD (Doctor of Dental Medicine) degrees, and may include initiated honorary members.

These include: In addition, Psi Omega provides a variety of insurance programs popular among members and alumni through group purchasing discounts.

[5] The badge of the Psi Omega Fraternity is an heraldic shield of gold with a slightly curved field of black enamel on which are displayed a caduceus, the letters ΨΩ, and three ivy-leaves.