Psilocybe meridionalis is a psychedelic mushroom which has psilocybin and psilocin as main active compounds.

This mushroom is closely related to Psilocybe stuntzii but can be distinguished by its smaller spores and the presence of pleurocystidia.

This is the only species of Psilocybe from section Stuntzii which has been found in Mexico.

It is known only from the type location in Neverias, Sierra de Cacoma, Jalisco, Mexico.

Found in Oak and Pine subtropical forests in the western mountains of Jalisco, Mexico.