[1][2] It is named for the Zapotec Indians, who are native to the Sierra Madre mountains of Oaxaca Mexico, as well as the area they inhabited.

[3] Other sources give the Zapotec name as badao zoo translated as "hongo borracho", "drunken mushroom".

Psilocybe zapotecorum gills are a cream color when young and violet brown in age, with an attachment that is sinuate or adnate, and sometimes subdecurrent.

The spores are dark violet brown, oblong to subellipsoid to subrhomboid, and thin-walled with a short apiculus and truncate germ pore.

The entire stem is covered with many white scales which are more pronounced in the lower part of the stipe.

Psilocybe zapotecorum is often found in subtropical forests containing Alnus sp., Magnolia sp., Fraxinus sp., Quercus sp., large pines, and blackberry bushes.

Psilocybe zapotecorum grows in Argentina, Brazil, Chile, Colombia, Mexico, Peru, Guatemala, El Salvador, Venezuela, Nicaragua and Ecuador.