The members are young people (assumed late teens to early twenties) altered by genetic, chemical, or biosurgical means by Harmon Furmintz of the Genetech Corporation to gain superpowers.

[4] After an extended run of crime-fighting in which much excessive force is used to apprehend criminals, the team becomes wanted by the law after a boy dies in an encounter with Asylum, and Psionex is again opposed by the New Warriors.

Though the death is ruled accidental (an undiagnosed heart condition determined as the cause), Asylum eventually takes responsibility and submits to police custody, while the rest of Psionex return to Genetech for observation.

[6] Psionex has not operated as their own team since the second Asylum's departure, though at least one member, Pretty Persuasions, has appeared out of Genetech's custody and at large (in the pages of New Thunderbolts, again employed as an exotic dancer).

During the Superhero Civil War, the individual members of Psionex (excepting either incarnation of Asylum) are apprehended by agents of the United States government who are enforcing the Superhuman Registration Act.