The leaves are directly attached to the stems or have a very short leaf stalk, and are opposite one another.

[4] Later studies determined that P. febrifugum had a wide array of chemicals like alkaloids, flavonoids, phenols, and tannins; the species also has higher quantities and densities of these chemicals than Harungana madagascariensis, another member of Hypericaceae with known medicinal qualities.

[5] Psorospermum febrifugum has been used as a febrifuge, leprosy treatment, antidote, and purgative.

[4] As an ethnomedicine in Tanzania and among the Baganda people of Uganda, is has also been used to treat epilepsy, pneumonia, and tuberculosis.

[3] A 1972 study demonstrated that ethanol extracts of the plant exhibited activity in a laboratory setting against leukemia in mice and a human cell line.