It is an official journal of the International Society of Psychoneuroendocrinology and was established in 1976.

The editor-in-chief is Elizabeth Shirtcliff (University of Oregon).

The journal publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on studies integrating these disciplines in terms of either basic research or clinical implications.

The journal and society support the "Bruce McEwen Lifetime Achievement award" for contributions to the understanding of brain-body interactions and the "Dirk Hellhammer award" to distinguished young investigators in the field of psychoneuroendocrinology.

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