Psyllobora vigintiduopunctata (often abbreviated to Psyllobora 22-punctata), the 22-spot ladybird, (earlier known as Thea vigintiduopunctata) is a common, 3–5 mm long ladybird native to Europe.

[2] This species was originally discovered in Germany in 1874 on the leaves of Astragalus, consuming the hyphae of Erysiphe holosericea.

[3] The elytra are yellow in colour with 22 black spots.

[4] Unlike most other ladybirds which feed on aphids, P. 22-punctata eats mildew — especially from umbellifers and low-growing shrubs .

[6] The hemolymph of the 22-spot ladybird beetle contains a new dimeric alkaloid, psylloborine A, which has unique structural features, highlighting the species' complex chemical defenses and evolutionary adaptations.