Puerto Rico Highway 106 (PR-106) is a road that travels from Mayagüez, Puerto Rico to Las Marías.

[2] It begins at its intersection with PR-239 (former PR-2R) in downtown Mayagüez and ends at its junction with PR-120 in southern Las Marías, near Maricao.

[3] Its eastern segment, from PR-119 to PR-120, is part of the Ruta Panorámica.

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