In San Germán, it begins at PR-2 and ends at PR-166,[3] and in Lajas, it extends from PR-116 to PR-321.

[4] When completed, it will be extend from PR-116 at its southern terminus to PR-2 interchange in the northern end.

PR-122 is mostly an avenue connecting downtown San Germán with PR-2.

[5] On June 22, 2023, the Governor of Puerto Rico announced that a budget has been assigned to build the last segment of PR-122 between San Germán and Lajas at an estimated cost of $53.3 million.

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