Puerto Rico Highway 578 (PR-578) is tertiary[2] state highway in Ponce, Puerto Rico.

The road runs from east to west, parallel to PR-1, and it forms the boundary between the northern end of barrio Bucaná and the southern end of barrio Sabanetas.

The road is located entirely within the municipality of Ponce.

[3] The entire route is located in Ponce.

This Puerto Rico road-related article is a stub.