Puerto Rico Highway 901 (PR-901) is a highway in the southeast coast of Puerto Rico which begins at its junction with PR-182 in Yabucoa and ends at its intersection with PR-760 in Manuabo.

PR-3 in Yabucoa enters downtown and continues uphill into the mountains.

The Puerto Rico Department of Transportation designed PR-901 as a primary route[4] while PR-53 is under construction, because it is a more direct way to the Maunabo area than PR-3, as the latter has more curves.

When PR-53 is finished, PR-901 will become a normal rural road, and PR-53 will become the primary route to Maunabo.

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