Pumiliotoxin

Pumiliotoxins (PTXs), are one of several toxins found in the skin of poison dart frogs.

The frog species, P. bibronii also produces PTXs to deter predators.

Other toxins found in the skin of poison frogs include decahydroquinolines (DHQs), izidines, coccinellines, and spiropyrrolizidine alkaloids.

Pumiliotoxins are much weaker than batrachotoxins, ranging between 100 and 1000 times less poisonous.

There are three different types of this toxin: A, B and C, of which toxins A and B are more toxic than C. Pumiliotoxins interfere with muscle contraction by affecting calcium channels, causing partial paralysis, difficulty moving, hyperactivity,[1] or death.