Pupiana was an ancient city and former bishopric in present-day Tunisia.
Pupiana was located near the modern Mra-Mita, Ain-Ouassel.
It was important enough in the Roman province of Africa proconsularis to become a suffragan of its capital's Metropolitan Archbishopric Carthage, but faded.
The diocese was nominally restored as Pupiana, temporarily renamed Papiana in 1923–1929; the Italian curiate form is Papia.
It has had the following incumbents, of the lowest (episcopal) rank :