It flows eastward, between the mountains of Radan (to the south) and Pasjača (to the north), next to the villages of Dobra Voda, Magaš, Brestovac and Velika Crkvica, before it reaches the regional center of Bojnik, after which, for the rest of its 46 km course, it is known as the Pusta River.

From Bojnik, the river bends north, next to the villages of Dragovac, Pridvorica, Đinđuša, Lapotince, Kacabać, Kosančić, Donje Brijanje, Međa and Draškovac, before it empties into the South Morava, near the village of Pukovac.

The Pusta River drains an area of 590 km2,[2] belongs to the Black Sea drainage basin, and is not navigable.

It is located between the Pasjača mountain and lower Toplica region (on the north), the Southern Pomoravlje (Leskovac Valley [sr], on the east), the Jablanica region (on the south) and the Radan mountain (on the west).

As if it confirms the name of the river (Pusta reka in Serbian means 'Desolate river'), the region is economically undeveloped and poor, sparsely populated and depopulating (18,801 inhabitants in 1971 or 71 per km2; 13,118 in 2002 or 50 per km2).