Pyrovalerone (Centroton, 4-Methyl-β-keto-prolintane, Thymergix, O-2371)[2] is a central nervous system (CNS) stimulant that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI).

It was developed in the 1980s and had briefly been approved in Spain and France for chronic fatigue or lethargy[3] and as an appetite suppressant, but was withdrawn from both markets around 2001 due to safety concerns including problems with abuse and dependence.

[4] It is closely related on a structural level to a number of other cathinone stimulants, such as α-PVP, MDPV and prolintane.

Side effects of pyrovalerone include decreased appetite, anxiety, fragmented sleep or insomnia, and trembling, shaking, or muscle tremors.

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