Pythio (Greek: Πύθιο, Turkish: Kuleliburgaz), also referred to as Pythion (Πύθιον), is a village and community in the eastern part of Didymoteicho municipality, Evros regional unit, Greece.

It is 16 km east of the centre of Didymoteicho, on the right bank of the river Evros, where it forms the border with Turkey.

The railway reached Pythio, known as Kuleliburgaz during Ottoman rule,[2] in 1873, when the line from Istanbul to Edirne and Bulgaria was opened.

During World War I the railway was an important link as the Ottoman Empire, Bulgaria and Austria-Hungary were all Central Allies.

In Greece a line was opened to allow trains from Pythio to Bulgaria to stay on Greek territory and avoid Edirne.