Koufovouno (Greek: Κουφόβουνο) is a settlement in the municipality of Didymoteicho in the northern Evros regional unit, Greece.
It is situated on a low hill near the right bank of the river Erythropotamos, at 70 m elevation.
During the Ottoman period, Koufovouno was inhabited mostly by Bulgarians and Turks.
It was occupied by the Greeks at the end of World War I and it became a part of Greece.
Its current population is mostly descendants of Greek refugees from Eastern Thrace.