Koufovouno (Greek: Κουφόβουνο) is a settlement in the municipality of Didymoteicho in the northern Evros regional unit, Greece.

It is situated on a low hill near the right bank of the river Erythropotamos, at 70 m elevation.

During the Ottoman period, Koufovouno was inhabited mostly by Bulgarians and Turks.

It was occupied by the Greeks at the end of World War I and it became a part of Greece.

Its current population is mostly descendants of Greek refugees from Eastern Thrace.