The best available evidence suggests that the Pyu script gradually developed between the 2nd and 6th centuries CE.

The early period Pyu inscriptions always included interlinear Brahmi scripts.

It was not until the 7th and 8th centuries that Sri Ksetra's inscriptions appeared all in the Pyu script, without any interlinear Brahmi.

[1] Many of the important inscriptions were written in Sanskrit and Pali, alongside the Pyu script.

Its inclusion was proposed in 2010,[3] and has tentative placement in the Unicode Consortium's roadmap.