The foundation of Quail Hollow Club is traced back to a meeting held by James J. Harris on April 13, 1959.

Opened on June 3, 1961, it underwent a series of improvements, including modifications of several holes by Arnold Palmer in 1986, and a redesign by Tom Fazio in 1997, 2003, and from 2014 to 2016 in preparation for the PGA Championship.

Additionally the club hosted the 2017 PGA Championship and that year the Wells Fargo was held at Eagle Point in Wilmington, North Carolina.

[11] In 2022, Quail Hollow hosted the fourteenth edition of the Presidents Cup; postponed from 2021 due to the COVID-19 Pandemic.

In a partnership with Penn Entertainment, Quail Hollow joined the North Carolina online sports betting movement.