Night Shift Nurses is the North American localization of Yakin Byōtō (夜勤病棟), a Japanese OVA series adapted by Discovery[1] from the visual novel of the same name.

[4][5] Night Shift Nurses, as was originally written for the game, takes place in an undisclosed area of Japan, mainly at the fictional St. Juliana Hospital.

After an acquaintance with Ren Nanase, a nurse who escorts him to the president, he is frightened to discover his potential employer is a woman he had brutally raped in the past, Narumi Jinguji.

In spite of the excruciating atmosphere, however, Narumi explains her wish to develop a department in the hospital that caters to the sexual interests of patients; in need of his expertise to oversee the operation.

[7] Yakin Byōto 2: A young elite doctor Souichiro Kuwabara couldn't forget his feelings towards Ren Nanase, whom he had fallen in love with back in his training days.

[9] Industry aggregator Mania.com gave the series an F, citing that although the animation is "clean" and "slick", the quantity of edits made for the American release yields it one that "[...]I in no way [can] recommend."