The site occupied by QASMT was formerly Toowong College; this location was chosen "to capitalise on its close educational and geographic links with the University of Queensland.

"[5] The site was occupied by the house known as Ormlie originally and later as Easton Gray and owned by Sir Arthur Hunter Palmer, Premier of Queensland[6] and subsequently the residence of his brother-in-law Hugh Mosman (who discovered gold at Charters Towers).

In 2008, the Queensland Academy for Health Sciences (QAHS) was developed in partnership with Griffith University with a focus on medicine, dentistry, physiotherapy, optometry, and medical research.

[9] The construction of the new Eastern Science, Technology, Engineering, and Mathematics building (L-Block) was completed in December 2019.

[14] “Queensland Academy for Science Mathematics and Technology principal and deputy accused of giving jobs to relatives”.