[1][2] QSS was officially opened by Lim Teck Hin, Member of Parliament for Tiong Bahru, on 2 September 1961.

In 1975, two new classroom blocks were built to cater to the increased enrolment.

In 2000, Queensway accepted students from Mei Chin Secondary School, which had closed down, and had also merged with Buona Vista Secondary School in January 2001.

The school has since undergone a rebuilding programme in 1999 and the new campus was completed on the same historical site in December 2001.

The new Indoor Sports Hall and Atrium was completed in July 2009 and officially opened by Baey Yam Keng, Member of Parliament for Tanjong Pagar GRC, on 15 April 2011.