[1] In addition to the main location, Quimby's NYC opened in 2017 at 536 Metropolitan Ave in the Williamsburg neighborhood of Brooklyn, New York.

Quimby's specializes in selling independently published and small press books, zines, comics, and ephemera, describing its collection as favoring "the unusual, the aberrant, the saucy and the lowbrow".

[4] Along with a curated selection of traditionally published books, Quimby's Bookstore sells independent publications, often featuring bizarre or unusual subject matter.

[9][10] Quimby's Chicago is a long time supporter of zinesters and comic artists such as John Porcellino and former employee Edie Fake.

[14][1] By the mid-1990s, Quimby's was a Wicker Park mainstay and helped define the neighborhood "as a national epicenter of cutting-edge underground culture and cool".