It was the largest hotel in Boston in the late 19th century,[3] and was a popular destination for prominent guests to the city.

[8] The regular union presence at the Quincy House eventually resulted in the hotel advertising itself as the "official headquarters for organized labor" in the city.

[9] The Quincy House additionally served as a popular place for local politicians, and it especially became known as the meeting place of the Board of Strategy, a group of high-ranking Democratic politicians (including P. J. Kennedy) who selected candidates for office and distributed patronage to party loyalists.

[3][10][11] The Quincy House's popularity began to suffer in the early 20th century; labor patronage declined during this period,[8] and the building was eclipsed by newer hotels in the city.

[2] In late 1934, the banks decided to raze the hotel, and in early 1935 it was demolished and replaced with a parking lot.