Quiriego is located east of Ciudad Obregón and is connected by dirt road with the main Federal Highway 15 at the village of Fundición.

Located in this region are the ruins of the ancient Real de Minas y Villa de Baroyeca, which was one of the most important settlements in Sonora during the colonial period and beginning of the post-independence era.

The municipal seat, Quiriego, was originally a ranch belonging to Francisco Javier Valenzuela in the last years of the eighteenth century.

Neighboring municipalities are Rosario to the north, Álamos to the east, Navojoa and the state of Chihuahua to the south, and Cajeme to the west.

Main crops are watermelon, sorghum, corn, beans, and grasses for cattle raising.