[1] She was the daughter of the Sapa Inca Huayna Capac and one of his secondary wives – the curaca of Huaylas, Contarhuacho.
She was baptized as Inés Huaylas Yupanqui when she was married via common law at a young age to conquistador Francisco Pizarro, as conquerors did with the women of the royal families they conquered and subordinated.
Quispe Sisa then married Conquistador Francisco de Ampuero.
During the siege of Lima, led by Manco Inca Yupanqui, Quispe Sisa sent several runners with messages to her mother in Huaylas, asking for help.
On September 12, 1536, her mother Contarhuacho sent in an army to help Pizarro defend Lima.