Quitaque Creek is an intermittent stream about 40 mi (64 km) long, originating as a shallow draw on the high plains of the Llano Estacado in Floyd County, Texas, and flowing eastward to join the North Pease River in Motley County, Texas.

Quitaque Creek initially runs southeastward across north-central Floyd County and then drops off the Caprock of the Llano Estacado approximately 3 mi (5 km) east of South Plains.

The stream then continues in a northeasterly direction across the sparsely populated ranch lands of northeastern Floyd County.

[2] Overall, Quitaque Creek descends 1,123 ft (342 m) from its headwaters to its confluence with the North Pease River, passing through flat to moderately steep terrain along its course.

[3] In a letter written in 1967 by J. O. Kilmartin, Executive Secretary of Domestic Geographic Names, to a Miss Faye Farley of Houston, Kilmartin suggests that the name "Quitaque" appears to be related to the Quitaca Indians, one of the tribes that accompanied Juan Domínguez de Mendoza on his expedition from the middle Rio Grande to the interior of Texas in 1683-84.