[1] During his nominal reign Meskhetian lords revolted several times against Jaqelian rule.

In 1578 Ottomans started new war against Safavid Persia for the hole territory of Caucasus.

Pasha had decided to send Qvarqvare and his younger brother Manuchar to Constantinople for recognizing Ottoman absolute rule in Samtskhe.

In 1579 by the order of Sultan Murad III Ottomans divided Samtskhe-Saatabago into eight Sanjaks and established Childir Eyalet on the lands of Meskheti.

Qvarqvare IV was appointed as Christian ruler of Childir Eyalet, but his brother Manuchar converted to Islam under the name of Mustafa and became the Ottoman Pasha.