It is affiliated to the University of Mumbai and the first of twenty-four institutions established and managed by the Hyderabad (Sind) National Collegiate Board (HSNCB).

A variety of courses are offered by R. D. National College, ranging from engineering, pharmacy and education to arts science and commerce.

The college has a Gymkhana the facilities include a full set of weight and powerlifting equipment treadmill and Exercycle.

There are also UGC-sponsored certificate courses in Hindustani Classical Music, Odissi dance, Heritage Management, Beauty care, and Finishing school.

R. D. National College also has an active placement cell that provides information and guidance to the students regarding jobs and recruitment procedures in various companies.