[5][6] He is most noted for his contributions in the Human Proteome Project where he served as the Group Leader for the countries like India, Singapore, Taiwan and Thailand.
He worked in the USA as a visiting researcher at the Washington University School of Medicine and the National Institutes of Health.
[8] Sirdeshmukh worked at CCMB for more than two decades and headed the proteomics laboratory as director before joining the Institute of Bioinformatics (IOB) as a distinguished scientist.
[7] His research interests extend to the areas of protein and nucleic acid biochemistry and his previous work includes RNA processing, mRNA stability, structure-function relationship of ribonucleases and their regulation.
More recently, his interest has been in the areas of proteomics of gliomas – a major class of brain tumors and head and neck cancers.