The R49 (also sometimes known as the R47) is a provincial route in North West, South Africa that connects Mahikeng with the Botswana border at Kopfontein near Gaborone, via Zeerust.

[1] The R49 begins in the town centre of Mahikeng, at a junction with the N18 national route and the R503 road.

It begins as Shippard Street, going eastwards to form the northern border of the Mafikeng Game Reserve.

From the N18 junction, it goes east, then north-east, for 61 kilometres, through Ottoshoop, to meet the N4 national route (Platinum Highway) adjacent to Zeerust Solar Power Station.

The R49 heads northwards for 103 kilometres to end at the Kopfontein Border Post west of the Madikwe Game Reserve and become the A12 road (Tlokweng Road) on the Botswana side, which connects westwards to Gaborone (Capital of Botswana; 19 kilometres away).