The R500 is a Regional Route in South Africa that connects Magaliesburg with Parys via Carletonville and Fochville.

It proceeds southwards for a further 3 kilometres to meet the western end of the R41 route from Randfontein.

[1] From the R41 junction, the R500 continues southwards for 16 kilometres, bypassing Khutsong and the Abe Bailey Nature Reserve, to enter the towns of Oberholzer and Carletonville.

[1] Continuing south, it heads south-south-east for 12 kilometres to reach a junction with the N12 national route and then bypasses Fochville to the east.

From Fochville, the R500 heads southwards to intersect with the R54 road from Potchefstroom in the west and Vereeniging in the east.