The R529 is a Regional Route in Limpopo, South Africa that connects Giyani with Lenyenye via Letsitele.

[1] Its northern origin is a junction with the R81 in Giyani (south of the town centre).

From Giyani, it runs roughly south-west for 77 kilometres to reach a junction with the R71.

The R529 joins the R71 southwards for 2 kilometres, crossing the Groot Letaba River, before becoming its own road southwards.

It heads southwards for 15 kilometres, through Letsitele, to end at a junction with the R36 just south-east of Lenyenye.