The R546 is a Regional Route in South Africa that connects Kinross with Vrede via Evander and Standerton.

It is initially co-signed with the R547 southwards for a small distance before the R547 becomes its own road to the south-south-west, while the R546 heads south.

[1] From Evander, it goes southwards for 54 km, passing through the township of Embalenhle and the village of Charl Cilliers, to Standerton.

After meeting the R50 and R39, it goes south through the Standerton Central Business District to intersect with the R23 road coming from Heidelberg.

[1] The R546 continues southwards for 56 km, crossing into the Free State, to enter the town of Vrede, where the route ends at an intersection with the R34.